Dosage and administration
Vaginal use. 1.55 g of progesterone / animal for 7 days.
Using an applicator, insert one device into the vagina of the animal. The intravaginal device should stay in place for 7 days. In cycling cattle, the device has to be used in combination with a prostaglandin, injected 24 hours prior to removal of the device. In non cycling cattle, an injection of a prostaglandin must be done 24 hours prior to removal of the device and an injection of eCG at the time of removal.
Disinfection procedure: The applicator must be cleaned and disinfected in a non-irritating antiseptic solution before and after use and between each animal.
Applicator method of use and Insertion:
Bend the device before inserting in the applicator. Ensure the string is in the appropriate slot. Lightly lubricate the distal end of the applicator with an obstetrical lubricant. Clean the animal’s vulva before gently inserting the applicator in the vagina. Once the applicator has reached the fundus of the vagina, press on the handle to release the device. Remove the applicator gently and ensure the string is outside the vulva. Shorten the string according to animal’s size if necessary.
Removal: Remove 7 days after insertion by gently pulling on the exposed string.
Timing of insemination: Animals should be inseminated 56 hours after removal of the device.
The device is intended for single use only.
Contra-indications, warnings, etc
Do not use in sexually immature heifers. Do not use before 35 days have passed since previous calving. Do not use in animals suffering from infectious or non-infectious disease of the genital tract. Do not use in pregnant animals.
Special warnings for each target species The progesterone treatment alone, according to dosage regimen proposed, is not sufficient to induce oestrus and ovulation in all cycling females. In order to optimise the protocol, it is advisable to determine cycling ovarian activity before using the progesterone treatment. Animals in poor condition, whether from illness, inadequate nutrition, or other factors, may respond poorly to treatment.Special precautions for use in animals It is recommended to wait a minimum of 35 days following parturition before starting the treatment with this product.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Gloves must be worn when handling the product both during insertion and removal. Do not eat or drink when handling the product. Wash hands after use.
Adverse reactions During the course of the seven day treatment, the device may induce a mild local reaction (i.e. inflammation of the vaginal wall). A clinical study carried out with 319 cows and heifers has demonstrated that 25% of animals presented ropy or cloudy vulvar secretions at the device removal. This local reaction disappears rapidly without any treatment between removal and insemination and does not affect fertility at inseminations nor pregnancy rates.
Use during pregnancy or lactation Can be used during lactation. Do not use before 35 days have passed since previous calving. Laboratory studies in rat and rabbit, after intramuscular or subcutaneous administrations, at repeated high doses of progesterone, have produced evidence of foetotoxic effects. The use of the product is contra-indicated in pregnant cattle.
Withdrawal period
Meat and offal: zero days Milk: zero days During the treatment meat, offal and milk can be delivered for human consumption.
