Presentation
Chorulon is presented in vials as a white freeze-dried crystalline plug containing 1500 i.u. Chorionic Gonadotrophin PhEur together with a vial containing 5 ml solvent for reconstitution.
This product does not contain any antimicrobial preservatives.
Uses
The active ingredient of Chorulon, human Chorionic Gonadotrophin (hCG), is a complex glycoprotein with luteinising hormone (LH) activity. In the female, hCG can be used to promote maturation of the follicle, ovulation and the formation of the corpus luteum. In the male, Chorulon stimulates the production of testosterone and thus influences the development and maintenance of primary and secondary male sexual characteristics.
Chorulon can be used in the following fertility problems in domestic animals:
- cases of repeated failure of conception in cows and heifers
- induction of ovulation in mares and bitches
- cases of cystic ovaries in cows and heifers
- anoestrus in mares and bitches
- delayed ovulation, prolonged pro-oestrus in bitches
- deficiency in libido in male dogs
Dosage and administration
Reconstitute with the solvent provided, ensuring the freeze dried plug is fully dissolved. Administer by intramuscular or intravenous injection, observing the usual aseptic precautions.
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Species
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Indication
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Dosage and administration
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Cow, heifer
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Repeated failure of conception
Cystic ovarian disease (anoestrus, prolonged oestrus, nymphomania)
Enhancement of luteal function
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1500 iu- i.m. or i.v. at AI or mating
3000 iu - i.v.
1500 iu - i.m. 12 days after insemination or mating
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Mare
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Suboestrus (follicles > 2 cm in diameter)
Induction of ovulation
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1500 - 3000 iu - i.m. or i.v., repeat after 2 days if necessary
1500-3000 iu - i.m. or i.v. 24 hours before AI or mating
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Bitch
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Anoestrus
Delayed ovulation, prolonged pro-oestrus
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500 iu - i.m. or i.v. at first day of oestrus after pretreatment with PMSG 20 iu/kg s.c. daily for 10 days.
100-800 iu / day i.m., repeating treatment until vaginal bleeding disappears. Mate on behavioural oestrus
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Male dog
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Deficiency in libido
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100-500 iu - i.m. twice weekly for up to 6 weeks, but if this is not possible then 100-500 iu i.m. 6-12 hours before mating may give a temporary effect
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Chorulon has been used in cases of cryptorchidism in the dog prior to castration (100-500 iu i.m. twice weekly for up to 6 weeks). Treatment may be effective in some cases provided that the inguinal canal is patent, and that therapy commences early. Chorulon has intrinsic LH-like activity. Injection of 1500 iu 12 days after heat in cattle enhances the active life of the corpus luteum by 2 to 3 days, resulting in increased progesterone and suppression of oestradiol production. These changes are consistent with those observed after GnRH use at day 11-13 of the cycle and are believed to be responsible for the increased pregnancy rates seen after such use. The mode of action is however different, since Chorulon does not rely on first stimulating an endogenous LH peak. This use of Chorulon has not been investigated in the field.
Contra-indications, warnings, etc.
In rare cases, as with all protein preparations, anaphylactoid incidents may occur shortly after injection. Adrenalin injection (1:1,000) given intravenously or intramuscularly when symptoms appear is the standard treatment. The administration of corticosteroids may also be indicated.
User warning
Care should be taken to avoid accidental self-injection.
If accidental self -injection occurs, seek medical advice immediately and show the doctor this package leaflet.
Withdrawal periods:
Cattle: Meat/ Milk - zero days.
Horses: Meat – zero days.
FOR ANIMAL TREATMENT ONLY. KEEP OUT OF REACH OF CHILDREN.
