MEDICINAL INGREDIENTS:
Lincomycin (as lincomycin hydrochloride), 50 mg/mL and spectinomycin (as spectinomycin sulfate), 100 mg/mL
PRESERVATIVE: Benzyl alcohol, 9 mg/mL
DESCRIPTION:
Lincomycin is an antibiotic produced by Streptomyces lincolnensis and is chemically distinct from all other clinically available antibiotics. It is readily soluble in water. It is effective in vitro against most of the common gram-positive pathogens.
Spectinomycin is an antibiotic produced by Streptomyces flavopersicus. Spectinomycin free base is weakly basic and readily soluble in water. It has in vivo and in vitro activity against many gram-positive and gram-negative organisms but, like lincomycin, is inactive against yeasts, molds, and viruses.
INDICATIONS:
For the treatment of infections in dogs and cats caused by Staphylococcus aureus, Pasteurella multocida, Streptococcus spp. and Mycoplasma spp.
Dogs: Linco-Spectin Sterile Solution has demonstrated efficacy in the treatment of respiratory infections, skin diseases and urinary tract infections. Specifically, infections successfully treated with Linco-SpectinSterile Solution include pneumonia, pharyngitis, tonsillitis, bronchitis, pyogenic dermatitis, pustular dermatitis, abscesses, cystitis and metritis.
Cats: Linco-Spectin Sterile Solution has demonstrated efficacy in the treatment of urinary tract and upper respiratory tract infections and localized infections. Infections successfully treated with Linco-Spectin Sterile Solution in cats include cystitis, upper respiratory tract infections, and infected fight wounds and abscesses.
DOSAGE AND ADMINISTRATION:
Linco-Spectin Sterile Solution is for intramuscular injection only.
Dosage may be calculated on the basis of spectinomycin content so as to provide 20 mg spectinomycin per kg body weight, or 1.0 mL Linco-Spectin Sterile Solution per 5 kg body weight.
The dose may be repeated at 12 - 24 hour intervals for up to 21 days. Monitoring of patients should be carried out to assure safety and efficacy of Linco-Spectin Sterile Solution when treating conditions that require prolonged therapy. As with all antibiotics, it is recommended that in vitro sensitivity studies be conducted as a basis for selection of Linco-Spectin Sterile Solution.
ADVERSE REACTIONS:
Diarrhea was reported to have occurred in two cats treated with Linco-Spectin Sterile Solution. Neither case required adjunctive therapy to correct the diarrhea following drug withdrawal.
Some decrease in appetite was observed in one dog treated for ten days with Linco-Spectin Sterile Solution. Several investigators reported observing signs of pain upon injection, but serious inflammatory reactions following injection have not been reported.
CONTRAINDICATIONS:
(1) As with all drugs, the administration of Linco-Spectin Sterile Solution is contraindicated in animals previously found to be hypersensitive to either lincomycin or spectinomycin or to the combination. (2) Lincomycin has been demonstrated to be toxic for rabbits, guinea pigs, hamsters and chinchillas. Linco-Spectin Sterile Solution is, therefore, contraindicated in these species.
WARNINGS:
For intramuscular use in dogs and cats only. Keep out of reach of children.
CAUTIONS:
Linco-Spectin Sterile Solution, like any drug, should be used with caution in animals with a history of significant allergies.
